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The states of California and Florida supply diazepam to condemned inmates for a pre-execution sedative as component of their lethal injection plan, although the point out of California has not executed a prisoner considering that 2006.
fentanyl transdermal and diazepam both equally enhance sedation. Stay clear of or Use Alternate Drug. Limit use to patients for whom option procedure solutions are inadequate
Benzodiazepines may possibly increase dangers of abuse, misuse, and addiction, which can lead to overdose or Demise
As diazepam rectal gel is only meant for adjunctive use, the prescriber must make sure the individual is obtaining an exceptional program of ordinary anti-epileptic drug treatment and it is, Even so, continuing to encounter these characteristic episodes
deferasirox will lessen the extent or impact of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Check.
etravirine will lower the level or influence of diazepam by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Check.
Lencapavir (a average CYP3A4 inhibitor) might raise CYP3A4 substrates initiated within nine months after last SC dose more info of lenacapavir, which may raise possible threat of adverse reactions of CYP3A4 substrates.
Watch Carefully (one)methylphenidate transdermal will increase the stage or influence of diazepam by lowering metabolism.
Propylene glycol toxicity claimed in people dealt with with diazepam injection at doses noticeably increased than advised when it absolutely was being used to take care of Liquor withdrawal signs at doses >900 mg/day Propylene glycol toxicity is related to an anion gap metabolic acidosis, serum hyperosmolality, and increased lactate
fentanyl iontophoretic transdermal technique and diazepam the two improve sedation. Steer clear of or Use Alternate Drug. Restrict use to individuals for whom different cure possibilities are inadequate
cobicistat will enhance the amount or influence of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep an eye on Closely. A lessened dose of diazepam could possibly be needed
apalutamide will minimize the level or result of diazepam by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a powerful CYP3A4 inducer, with drugs which might be CYP3A4 substrates may result in lower exposure to those prescription drugs.
Pitfalls of dependence and withdrawal raise with for a longer time therapy length and better day-to-day dose; Whilst injection is indicated only for intermittent use, if made use of a lot more frequently than advisable, abrupt discontinuation or rapid dosage reduction may precipitate acute
Lonafarnib could increase the AUC and peak focus of CYP2C19 substrates. If coadministration unavoidable, keep track of for adverse reactions and lessen the CYP2C19 substrate dose in accordance with its permitted product or service labeling.